https://www.pharmatlas.org/ 2026-04-16T22:01:44+00:00 https://www.pharmatlas.org/ https://www.pharmatlas.org/lib/exe/fetch.php?media=logo.png text/html 2026-02-12T21:16:26+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.pharmatlas.org/doku.php?id=allergy:drug_classes:first_generation_h1&rev=1770930986&do=diff First-Generation Antihistamines First-generation antihistamines are H1 receptor antagonists that cross the blood-brain barrier and produce central sedation. See histamine physiology: * Histamine Physiology * Type I Hypersensitivity Second-generation agents: * Second-Generation Antihistamines ---------- Mechanism of Action text/html 2026-02-12T19:31:43+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.pharmatlas.org/doku.php?id=allergy:drug_classes:second_generation_h1&rev=1770924703&do=diff Second-Generation H1 Antihistamines These agents are selective peripheral H1 receptor inverse agonists with minimal central nervous system penetration. Primary use: * Allergic Rhinitis * Chronic urticaria * Pruritus ---------- Side-by-Side Comparison Drug