Hydrocortisone

• Short-acting systemic glucocorticoid
• Also available topical and rectal

Parent class:

• Corticosteroids

Binds intracellular glucocorticoid receptor → alters gene transcription → broad anti-inflammatory effects.

Has moderate mineralocorticoid activity.

See:

• Glucocorticoid Signaling

Systemic:

• Adrenal Insufficiency
• Adrenal crisis
• Severe inflammation

Topical:

• Dermatitis

Rectal:

• Ulcerative proctitis

• Closest synthetic analog to cortisol.
• Preferred for adrenal replacement therapy.
• Has sodium-retaining effects.