Moexipril is an ACE inhibitor used primarily for hypertension.
It is less commonly prescribed compared to lisinopril or enalapril.
Class: → ACE Inhibitors
• Inhibits Angiotensin-Converting Enzyme (ACE) • ↓ Angiotensin II • ↓ Aldosterone • ↑ Bradykinin
Net Effects: • ↓ Systemic vascular resistance • ↓ Blood pressure • ↓ Sodium retention
Mechanism identical to other ACE inhibitors.
• Prodrug (converted to active moexiprilat) • Shorter duration compared to lisinopril • Absorption reduced by food (take 1 hour before meals)
Because of food effect and less convenient dosing, rarely first-line in modern practice.
• Approved for treatment of hypertension • Not commonly used for heart failure compared to other ACE inhibitors
Hypertension: • Start: 7.5 mg once daily (1 hour before meals) • Typical range: 7.5–30 mg daily (once or divided)
May require twice-daily dosing.
• Prodrug → activated in liver • Renally cleared • Reduced bioavailability with food • Half-life ~2–9 hours (active metabolite)
Dose adjustment required in renal impairment.
Class Effects: • Dry cough • Hyperkalemia • Hypotension • Angioedema (rare)
No major differences from other ACE inhibitors.
Monitor: • Serum creatinine • Potassium
Check labs within 1–2 weeks of initiation or dose changes.
• Pregnancy • History of ACE inhibitor–induced angioedema • Bilateral renal artery stenosis
✔ Less commonly used ACE inhibitor ✔ Must be taken before meals ✔ Similar efficacy to other ACE inhibitors ✔ No clear advantage over more commonly used agents
Related:
→ ACE Inhibitors → Lisinopril → Enalapril → Return to CV Modules