Differences

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--- office_hours:inflammation:start [2026/02/15 17:48] – [High-Yield Framework] andrew2393cns
+++ office_hours:inflammation:start [2026/02/15 17:52] (current) – [High-Yield Framework — How Immune Drugs Differ] andrew2393cns
@@ Line 25: / Line 25: @@
 <WRAP center round box 95%>
-If you understand the pathway, you stop memorizing drug lists.
+You will be a better clinician if you understand the pathways, not just memorize some drugs
 </WRAP>
@@ Line 109: / Line 109: @@
-===== High-Yield Framework =====
+===== High-Yield Framework — How Immune Drugs Differ =====
-<WRAP center 90%>
+<WRAP center 95%>
-^ Target Level ^ Examples ^ What It Usually Does ^
+^ Depth of Action ^ What The Drug Is Really Doing ^ Drug Classes ^ Typical Clinical Use ^
-| Mast cells / histamine | [[allergy:drug_classes:first_generation_h1|Antihistamines]], [[immunology:biologics:anti_ige|Omalizumab (IgE)]] | helps allergy symptoms; not great for deep autoimmune disease |
+| Surface (symptom relief) | Blocks mediators already released | [[allergy:drug_classes:first_generation_h1|Antihistamines]], [[immunology:biologics:anti_ige|Omalizumab]] | Seasonal allergies, urticaria |
-| Arachidonic acid (COX/LOX) | [[eicosanoids:nsaids:start|NSAIDs]], [[cardio:antiplatelet:aspirin|Aspirin]], [[respiratory:leukotriene_modifiers:5lo|Zileuton]], [[respiratory:drugs:montelukast|Montelukast]] | pain/fever/inflammation; leukotrienes = airway + allergy |
+| Local chemical inflammation | Blocks inflammatory chemicals (prostaglandins / leukotrienes) | [[eicosanoids:nsaids:start|NSAIDs]], [[cardio:antiplatelet:aspirin|Aspirin]], [[respiratory:drugs:zileuton|Zileuton]], [[respiratory:drugs:montelukast|Montelukast]] | Pain, fever, mild asthma |
-| Gene transcription | [[immunology:corticosteroids:start|Corticosteroids]] | broad suppression; powerful but lots of systemic adverse effects |
+| Broad immune suppression | Turns off inflammatory gene production | [[endocrine:drug_classes:corticosteroids|Corticosteroids]] | Severe inflammation, flares |
-| Cytokines / signaling | [[immunology:biologics:anti_tnf_agents|TNF inhibitors]], [[immunology:biologics:start|IL inhibitors]], [[immunology:jak_inhibitors:start|JAK inhibitors]] | “upstream” control; high impact in autoimmune disease |
+| Targeted immune modulation | Blocks specific immune communication pathways | [[immunology:biologics:anti_tnf_agents|TNF inhibitors]], [[immunology:biologics:start|IL inhibitors]], [[immunology:jak_inhibitors:start|JAK inhibitors]] | Autoimmune disease, severe asthma, IBD |
 </WRAP>
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+<WRAP center round tip 90%>
+The deeper the drug acts → the stronger the disease control → the greater the infection risk.
+</WRAP>
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 ===== Related =====