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| neuro:opioids:start [2026/02/15 02:47] – andrew2393cns | neuro:opioids:start [2026/02/15 02:49] (current) – andrew2393cns |
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| | [[neuro:opioids:hydrocodone|Hydrocodone]] | Hysingla ER | Full μ agonist | Full agonist | ~1x | Often combined with acetaminophen | | | [[neuro:opioids:hydrocodone|Hydrocodone]] | Hysingla ER | Full μ agonist | Full agonist | ~1x | Often combined with acetaminophen | |
| | [[neuro:opioids:methadone|Methadone]] | Dolophine | Full μ agonist + NMDA antagonist | Full agonist | Variable | Long half-life; QT prolongation | | | [[neuro:opioids:methadone|Methadone]] | Dolophine | Full μ agonist + NMDA antagonist | Full agonist | Variable | Long half-life; QT prolongation | |
| | [[neuro:opioids:tapentadol|Tapentadol]] | Nucynta | μ agonist + Norepinephrine reuptake inhibition | Dual mechanism | ~0.4x | Less serotonergic than tramadol | | | [[neuro:opioids:tapentadol|Tapentadol]] | Nucynta | Weak μ agonist + Norepinephrine reuptake inhibition | Dual mechanism | ~0.4x | Less serotonergic than tramadol | |
| | [[neuro:opioids:tramadol|Tramadol]] | Ultram | Weak μ agonist + SNRI | Weak agonist | ~0.1x | Serotonin syndrome risk | | | [[neuro:opioids:tramadol|Tramadol]] | Ultram | Weak μ agonist + SNRI | Weak agonist | ~0.1x | Serotonin syndrome risk. Lowers seizure threshold | |
| | [[neuro:opioids:codeine|Codeine]] | — | Weak μ agonist (CYP2D6 prodrug) | Weak agonist | ~0.1x | Variable metabolism | | | [[neuro:opioids:codeine|Codeine]] | — | Weak μ agonist (CYP2D6 prodrug) | Weak agonist | ~0.1x | Variable metabolism | |
| | [[neuro:opioids:meperidine|Meperidine]] | Demerol | Full μ agonist | Full agonist | ~0.1x | Normeperidine → seizures | | | [[neuro:opioids:meperidine|Meperidine]] | Demerol | Full μ agonist | Full agonist | ~0.1x | Normeperidine → seizures | |
