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--- basics:start [2026/02/12 21:11] – [High-Yield Framework] andrew2393cns
+++ basics:start [2026/02/12 21:11] (current) – [High-Yield Framework] andrew2393cns
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+===== High-Yield Framework =====
+  * Innate immunity initiates inflammation.
+  * Adaptive immunity provides specificity and memory.
+  * Th1/Th17 drive autoimmune inflammation.
+  * Th2 drives allergic disease.
+  * COX pathway → prostaglandins.
+  * 5-LOX pathway → leukotrienes.
+  * NSAIDs block COX.
+  * COX-2 inhibitors selectively block inflammatory COX-2.
+  * Leukotriene modifiers block bronchoconstrictive leukotrienes.
+  * Corticosteroids suppress upstream inflammatory transcription.
+  * Biologics target specific cytokines.
+----
 ===== I. Core Immune Physiology =====
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   * [[immunology:biologics:abatacept|Abatacept]]