Differences

This shows you the differences between two versions of the page.

--- allergy:start [2026/02/12 19:13] – created andrew2393cns
+++ allergy:start [2026/02/15 03:11] (current) – [Leukotriene Pathway Modifiers] andrew2393cns
@@ Line 1: / Line 1: @@
-====== Histamine & Antihistamines ======
+====== Drugs For Allergy  ======
-**Focus:** Histamine signaling and pharmacologic control of allergic symptoms, with clinical links for common disease presentations (rhinitis, urticaria, anaphylaxis, asthma overlap).
+**Focus:** Histamine signaling and pharmacologic management of allergic disease.
+Organized by drug class with clinical treatment references below.
-[[#drug_classes|Drug Classes]] • [[#clinical_use|Clinical Use]] • [[#mechanisms|Mechanisms]] • [[#learning_tools|Learning Tools]]
 ----
-===== Drug Classes =====
-==== H1 Blockers ====
-  * [[allergy:histamine:h1_first_gen|H1 Antihistamines — 1st Generation (Sedating)]]
-  * [[allergy:histamine:h1_second_gen|H1 Antihistamines — 2nd Generation (Non-sedating)]]
-==== H2 Blockers (Adjunct) ====
+===== H1 Antihistamines — First Generation (Sedating) =====
-  * [[allergy:histamine:h2_blockers|H2 Blockers (Cimetidine, Famotidine, etc.)]]
-==== Mast Cell / Degranulation Inhibitors ====
+  * [[allergy:drugs:brompheniramine|Brompheniramine]]
-  * [[allergy:histamine:mast_cell_stabilizers|Mast Cell Stabilizers (Cromolyn, etc.)]]
+  * [[allergy:drugs:chlorpheniramine|Chlorpheniramine]]
+  * [[allergy:drugs:diphenhydramine|Diphenhydramine]]
+  * [[allergy:drugs:hydroxyzine|Hydroxyzine]]
+  * [[allergy:drugs:promethazine|Promethazine]]
+  * [[allergy:drugs:dimenhydrinate|Dimenhydrinate]]
+  * [[allergy:drugs:meclizine|Meclizine]]
-==== Leukotriene Pathway (Overlap with NSAIDs/Asthma) ====
+----
-  * [[allergy:histamine:leukotriene_modifiers|Leukotriene Modifiers (Montelukast, Zileuton)]]
+===== H1 Antihistamines — Second Generation (Non-Sedating) =====
+[[allergy:drug_classes:second_generation_h1|Second Generation Histamine-1 Antagonists]]
+  * [[allergy:drugs:fexofenadine|Fexofenadine]]
+  * [[allergy:drugs:loratadine|Loratadine]]
+  * [[allergy:drugs:cetirizine|Cetirizine]]
+  * [[allergy:drugs:levocetirizine|Levocetirizine]]
+  * [[allergy:drugs:desloratadine|Desloratadine]]
+----
+===== H2 Blockers =====
+  * [[gi:drugs:cimetidine|Cimetidine]]
+  * [[gi:drugs:famotidine|Famotidine]]
+  * [[gi:drugs:nizatidine|Nizatidine]]
+  * Ranitidine (off market)
+----
+===== Mast Cell Stabilizers =====
+  * [[allergy:drugs:cromolyn|Cromolyn Sodium]]
+  * Nedocromil (off market)
+----
+===== Leukotriene Pathway Modifiers =====
+[[respiratory:drug_classes:leukotriene_modifiers|Leukotriene Modifiers]]
+  * [[respiratory:drugs:montelukast|Montelukast]]
+  * [[respiratory:drugs:zafirlukast|Zafirlukast]]
+  * [[respiratory:drugs:zileuton|Zileuton]]
+----
+===== Corticosteroids in Allergy =====
+[[endocrine:drug_classes:Corticosteroids]]
+==== Intranasal ====
+  * [[endocrine:drugs:fluticasone|Fluticasone]]
+  * [[endocrine:drugs:mometasone|Mometasone]]
+  * [[endocrine:drugs:budesonide|Budesonide]]
+==== Systemic ====
+  * [[endocrine:drugs:prednisone|Prednisone]]
+  * [[endocrine:drugs:methylprednisolone|Methylprednisolone]]
+----
+===== Rescue Therapy =====
+  * [[cardio:drugs:epinephrine|Epinephrine]]
+----
-==== Steroids in Allergy ====
+===== Biologic Therapies For Allergy =====
-  * [[allergy:histamine:corticosteroids|Corticosteroids (intranasal, inhaled, systemic)]]
-==== Rescue / High-Stakes ====
+  * [[immunology:drugs:omalizumab|Omalizumab]]
-  * [[allergy:histamine:epinephrine|Epinephrine & Anaphylaxis Protocol]]
+  * [[immunology:drugs:mepolizumab|Mepolizumab]]
-  * [[allergy:histamine:biologics|Biologics (Anti-IgE, Anti-IL5, Anti-IL4/13)]]
+  * [[immunology:drugs:reslizumab|Reslizumab]]
+  * [[immunology:drugs:benralizumab|Benralizumab]]
+  * [[immunology:drugs:dupilumab|Dupilumab]]
 ----
@@ Line 32: / Line 84: @@
   * **Allergic Rhinitis** → [[allergy:clinical:allergic_rhinitis|Treatment & Stepwise Therapy]]
-    (intranasal steroid first-line; add antihistamine based on symptoms)
+    (Intranasal steroid first-line; add antihistamine based on symptoms)
   * **Urticaria / Pruritus** → [[allergy:clinical:urticaria_angioedema|Treatment Approach]]
-    (scheduled 2nd-gen H1 blockers; escalate; chronic urticaria options)
+    (Scheduled 2nd-gen H1 blockers; escalate; chronic urticaria options)
   * **Angioedema** → [[allergy:clinical:urticaria_angioedema|Histamine vs Bradykinin Angioedema]]
-    (distinguish allergic vs ACEi/HAE)
+    (Distinguish allergic vs ACEi/HAE)
   * **Anaphylaxis** → [[allergy:clinical:anaphylaxis|Emergency Algorithm]]
     (IM epinephrine first-line; adjuncts second)